Medical researchers from Columbia University have discovered that the ruxolitinib, Jakafi active ingredient of the drug, which is prescribed to treat myelofibrosis shown particularly effective in the treatment of alopecia areata. This disease, which causes hair loss is caused by an autoimmune mechanism, a type of lymphocytes accumulate around the hair follicle, playland causing hair loss.
The team of Luzhou Xing, Zhenpeng Dai, Ali Jabbari, Jane E Cerise, Claire A Higgins, Weijuan Gong, Annemieke de Jong, Silvan Harel, Gina DeStefano, Lisa Rothman, Pallavi Singh, Lynn Petukhova, Julian Mackay-Wiggan, Angela Christiano and Raphael Clynes, trialists mice and a small group of people, spectacular results have been published in the online edition of Nature Medicine.
The researchers identified the first immune cells that destroy follicles in alopecia, and found that these cells ruxolitinib eliminated. In addition to mice, the drug was tested in a group of patients, and three of them fully recovered hair after five months of oral treatment. One of the researchers, Raphael playland Clynes, has he stressed in a press release from Columbia that need to do more tests to categorically determine the ruxolitinib should be prescribed in alopecia areata, playland but "is great news for patients and physicians," said .
The Jakafi drug approved in the United States two years ago, in the European Union, is very expensive, could go for more than 6,000 euros a month in treating myelofibrosis and with many side effects like most cancer treatments .
A couple of months ago, another study of a scientific group of Yale in which he got a treaty experimentally a psoriasis patient recover all the hair after supply tofacitinib approved Pfizer under the name Xeljanz as anitrreumático was published and that is being tested for the treatment of psoriasis, linked to certain types of rheumatoid arthritis disease. Cheaper than Jakafi, but also with serious side effects, which led to the European Medicines Agency not to approve the sale.
Although seemingly encouraging these trials, all you have to do with the cure of alopecia have to watch very carefully because economic interests are brutal. If Jakafi, a drug developed by Incyte and licensed by Novartis, was effective for alopecia areata, the price would rise exponentially. The same is true of Xeljanz, marketed Pfizer.
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